Behavioural and cognitive changes in a patient with leukoencephalopathy due to lymphomatosis cerebri


A 59 years old female with a prior history of facial hemangioma, with a three-month progressive cognitive impairment (MoCA score 15/30) combined with abulia, unmotivated crying,  non-fluent language, limb paratonia, bilateral Hoffman and palmomental reflex; and apraxic gait.


Keywords: lymphomatosis cerebri, linfomatosis cerebri, leukoencephalopathy, leucoencefalopatía, PCNSL, LPSNC, Primary central nervous system lymphoma, Linfoma primario de sistema nervioso central


Bataille, B.; Delwail, V.; Menet, E.; Vandermarcq, P.; Ingrand, P.; Wager, M.; Guy, G. & Lapierre, F. (2000). Primary intracerebral malignant lymphoma: report of 248 cases. Journal of Neurosurgery, 92(2), 261–266.

Gerstner, E. R. & Batchelor, T. T. (2010). Primary central nervous system lymphoma. Archives of Neurology, 67(3), 291–297.

Grommes, C. & DeAngelis, L. M. (2017). Primary CNS Lymphoma. Journal of Clinical Oncology, 35(21), 2410–2418.

Izquierdo, C.; Velasco, R.; Vidal, N.; Sánchez, J. J.; Argyriou, A. A.; Besora, S.; Graus, F. & Bruna, J. (2016). Lymphomatosis cerebri: a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature. Neuro-Oncology, 18(5), 707–715.

Kitai, R.; Hashimoto, N.; Yamate, K.; Ikawa, M.; Yoneda, M.; Nakajima, T.; Arishima, H.; Takeuchi, H.; Sato, K. & Kikuta, K.-I. (2012). Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings. Brain Tumor Pathology, 29(1), 47–53.

Li, L.; Rong, J.-H. & Feng, J. (2018). Neuroradiological features of lymphomatosis cerebri: A systematic review of the English literature with a new case report. Oncology Letters, 16(2), 1463–1474.

Schaff, L. R. & Grommes, C. (2018). Updates on Primary Central Nervous System Lymphoma. Current Oncology Reports, 20(2), 1–10.

Waragai, M.; Takeuchi, H.; Fukushima, T.; Haisa, T. & Yonemitsu, T. (2006). MRI and SPECT studies of dural arteriovenous fistulas presenting as pure progressive dementia with leukoencephalopathy: a cause of treatable dementia. European Journal of Neurology, 13(7), 754–759.


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Crema, S., Ricciardi, M., & Calandri, I. (2021). Behavioural and cognitive changes in a patient with leukoencephalopathy due to lymphomatosis cerebri. Journal of Applied Cognitive Neuroscience, 2(2), e00193642. Retrieved from