Frontotemporal dementia: past, present and future
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https://orcid.org/0000-0002-7420-8547
Abstract
This scientific review comprehensively addresses frontotemporal dementia (FTD), providing a comprehensive overview of its historical evolution, clinical typology, underlying pathology, genetic basis and therapeutic approaches. The clinical diversity of FTD and the importance of understanding its distinctive symptomatic manifestations are highlighted. The review explores the pathology, highlighting the accumulation of proteins such as tau and TDP-43, and explores the genetic implications, with emphasis on key mutations such as MAPT, progranulin and c9orf72. In addition to reviewing pharmacological therapies, non-pharmacological approaches are examined, including cognitive stimulation strategies and psychosocial support. The synthesis includes critical analyses of emerging therapies, from innovative pharmacological interventions to technological developments. This scientific summary provides an updated view of FTD, fostering a comprehensive understanding of this complex clinical entity and highlighting promising avenues for the development of more effective and personalized therapeutic interventions.
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